Production of Cross-Tolerance to Psychosis-Producing Doses of Lysergic Acid Diethylamide and Psilocybin
The Journal of Psychology January 1, 1960 Harold A. Abramson, Anabela P. Rolo, B. Sklarofsky et al. 22 citations
In a small human experiment, participants who developed tolerance to lysergic acid diethylamide also showed cross-tolerance to psilocybin, meaning prior exposure to one drug reduced the effects of the other. The authors suggest that these two hallucinogens act through a common mechanism in the brain to produce psychosis-like states. The study provides early evidence for shared pharmacological pathways between LSD and psilocybin.