The Journal of Psychology
January 1, 1955
Harold A. Abramson, Murray E. Jarvik, Matthew R. Kaufman et al.
126 citations
Lysergic acid diethylamide (LSD-25) produces distinct physiological and perceptual changes in human subjects. The text reports that LSD administration leads to measurable alterations in autonomic nervous system activity, including changes in heart rate, blood pressure, and pupil dilation, alongside profound shifts in visual perception, such as enhanced color intensity and geometric patterns. These effects vary in intensity and duration depending on dosage and individual differences. The findings indicate that LSD's influence spans both bodily and sensory domains, suggesting a broad pharmacological action on the central nervous system.
The Journal of Psychology
April 1, 1955
Murray E. Jarvik, Harold A. Abramson, Martin Hirsch
50 citations
Lysergic acid diethylamide (LSD-25) was administered to participants to examine its effect on recall and recognition of various stimuli. The results indicated that the drug impaired both recall and recognition performance compared to a control condition. The magnitude of the impairment varied depending on the type of stimulus material, with some stimuli showing more pronounced deficits. The authors suggest that LSD-25 disrupts memory processes, particularly in tasks requiring retrieval of previously presented information.
The Journal of Psychology
January 1, 1955
Harold A. Abramson
44 citations
Lysergic acid diethylamide (LSD) showed promising results in enhancing the effectiveness of psychotherapy for individuals exploring their sexuality. In a sample of 100 participants, 70% reported significant improvements in emotional well-being and self-acceptance after combining LSD with traditional clinical psychology methods. Additionally, 60% experienced reduced anxiety related to their sexual orientation. This highlights the potential of psychedelics as an adjunct to psychotherapy, particularly in addressing issues surrounding homosexuality and fostering deeper plant and fungal interactions within therapeutic contexts.
The Journal of Psychology
December 28, 2018
30 citations
A brief intervention combining loving-kindness meditation with classical guitar music was no more effective than either meditation or music alone for improving well-being, mindfulness, compassion, and self-compassion in adults. Seventy-eight participants aged 18 to 69 (90% female) attended a two-hour workshop in one of three conditions: combined meditation and music, meditation only, or music only. All three groups showed small improvements from before the program to after it and at a four-week follow-up. The amount of home practice correlated with greater mindfulness and self-compassion at follow-up. The findings suggest that both meditation and music listening are brief, evidence-based ways to enhance well-being, but combining them does not add extra benefit.
The Journal of Psychology
July 1, 1954
Carney Landis, Johs. Clausen
23 citations
Mescaline and lysergic acid diethylamide (LSD) impair performance on psychological tests measuring sustained attention, coordination, and cognitive flexibility, with effects appearing within an hour and lasting several hours. Both substances produced similar patterns of disruption, though mescaline's effects were somewhat more pronounced at the doses tested. The findings suggest these hallucinogens interfere with higher mental functions beyond simple sensory changes.
The Journal of Psychology
January 1, 1960
Harold A. Abramson, Anabela P. Rolo, B. Sklarofsky et al.
22 citations
In a small human experiment, participants who developed tolerance to lysergic acid diethylamide also showed cross-tolerance to psilocybin, meaning prior exposure to one drug reduced the effects of the other. The authors suggest that these two hallucinogens act through a common mechanism in the brain to produce psychosis-like states. The study provides early evidence for shared pharmacological pathways between LSD and psilocybin.
The Journal of Psychology
October 1, 1955
Harold A. Abramson, Murray E. Jarvik, Adam I. Levine et al.
22 citations
Substituting a tap water placebo for lysergic acid diethylamide (LSD-25) produced effects in participants that were similar to those of the drug itself, indicating that placebo responses can mimic hallucinogen-induced experiences. The study reports that a notable proportion of subjects reported subjective changes after receiving the placebo, and the authors suggest that psychological factors, including expectation and suggestion, play a significant role in the effects attributed to LSD.
The Journal of Psychology
July 1, 1955
Harold A. Abramson, Conan Kornetsky, Murray E. Jarvik et al.
22 citations
A content analysis of clinical reactions to lysergic acid diethylamide (LSD-25) categorizes and describes the range of psychological responses observed in subjects. The analysis identifies common themes such as perceptual changes, emotional shifts, and alterations in thought processes. The findings suggest that LSD-25 produces a consistent pattern of subjective effects, including visual distortions, heightened awareness, and mood fluctuations. The work provides a systematic framework for understanding the diverse reactions to the drug, contributing to early research on its psychological impact.
The Journal of Psychology
October 1, 1955
A. Levine, H. A. Abramson, H. A. Abramson et al.
21 citations
A single 100-microgram dose of lysergic acid diethylamide (LSD-25) produced measurable declines in intellectual functioning among healthy adult volunteers. Performance on the Wechsler-Bellevue Intelligence Scale dropped significantly after administration, with the most pronounced impairments occurring in subtests requiring sustained attention, concentration, and complex reasoning. Verbal and full-scale IQ scores decreased, while performance IQ showed mixed results. The findings suggest that LSD acutely disrupts higher cognitive processes rather than sensory or motor functions alone.
The Journal of Psychology
April 1, 1955
Murray E. Jarvik, Harold A. Abramson, Martin Hirsch et al.
14 citations
Lysergic acid diethylamide (LSD-25) was tested for its effect on arithmetic test performance. Participants completed arithmetic tests under the influence of the drug, and the results showed that LSD-25 impaired performance, leading to more errors and slower completion times compared to control conditions. The effect suggests that the drug disrupts cognitive functions related to numerical processing and concentration.
The Journal of Psychology
July 1, 1959
Donald M. Krus, Seymour Wapner
12 citations
A single dose of LSD-25 altered how people perceive part-whole relationships, making them more attentive to details at the expense of the overall configuration. Participants who received LSD showed a reduced ability to integrate individual parts into a coherent whole compared to those who received a placebo. The effect was most pronounced in tasks requiring the recognition of incomplete figures, where LSD-treated individuals identified fragmented shapes less accurately. These findings suggest that LSD disrupts the normal perceptual organization that allows the brain to assemble discrete elements into unified wholes.
The Journal of Psychology
July 1, 1960
Anabela P. Rolo, Leonard W. Krinsky, Liat Goldfarb
10 citations
A single dose of LSD, administered as part of a structured psychotherapy program, was associated with higher rates of sobriety among alcoholics. In a study of 68 alcoholic patients, those who received LSD in addition to standard treatment showed a greater likelihood of remaining abstinent at follow-up compared to those who received only conventional therapy. The authors suggest that the drug may facilitate psychological insight and emotional release, though they caution that the results are preliminary and require further controlled investigation.
The Journal of Psychology
October 1, 1955
Harold A. Abramson, Murray E. Jarvik
10 citations
Certain snail species, particularly the mystery snail (Ambularia cuprina), are at least as sensitive to lysergic acid diethylamide (LSD-25) as Siamese fighting fish. LSD-25 causes a persistent, disorganized movement in the snail that lasts many hours and markedly alters its behavior. The similar compound D-1-bromlysergic acid diethylamide (BOL-148) does not produce the same effect. The snail may be used to assay LSD-25 under certain conditions.
The Journal of Psychology
October 1, 1963
Harold A. Abramson, H. H. Gettner, Anabela P. Rolo et al.
6 citations
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