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H. H. Gettner

2 papers in the library · 10 citations · publishing 1963-1979

Papers

The intracranial injection of drugs in goldfish. I: Hallucinogens and their antagonism to smooth muscle activity

Journal of Asthma Research January 1, 1979 Harold A. Abramson, H. H. Gettner, P. A. Carone et al. 4 citations

A simplified method for studying the surfacing reaction of goldfish to hallucinogens uses intracranial injection in fish weighing up to three grams. The drugs d-lysergic acid diethylamide (LSD-25), d-2-acetyl lysergic acid diethylamide (ALD-52), 1-methyl d-lysergic acid butanolamide (UML-491), and 5-methoxy dimethyl tryptamine (5-MEO-DMT) were as pharmacologically active as previously noted in fish and in humans. The relationship of these drugs to their anti-serotonin activity is of particular interest to allergists because the congeners and derivatives of LSD block the action of serotonin on smooth muscle.