A single dose of LSD, administered as part of a structured psychotherapy program, was associated with higher rates of sobriety among alcoholics. In a study of 68 alcoholic patients, those who received LSD in addition to standard treatment showed a greater likelihood of remaining abstinent at follow-up compared to those who received only conventional therapy. The authors suggest that the drug may facilitate psychological insight and emotional release, though they caution that the results are preliminary and require further controlled investigation.
A simplified method for studying the surfacing reaction of goldfish to hallucinogens uses intracranial injection in fish weighing up to three grams. The drugs d-lysergic acid diethylamide (LSD-25), d-2-acetyl lysergic acid diethylamide (ALD-52), 1-methyl d-lysergic acid butanolamide (UML-491), and 5-methoxy dimethyl tryptamine (5-MEO-DMT) were as pharmacologically active as previously noted in fish and in humans. The relationship of these drugs to their anti-serotonin activity is of particular interest to allergists because the congeners and derivatives of LSD block the action of serotonin on smooth muscle.