Methysergide (Sansert), a derivative of d-lysergic acid used to treat migraine, produces side effects and tolerance, leading researchers to compare its effects with those of LSD-25, psilocybin, and psilocin in non-psychotic test subjects over more than 150 experiments. The experimental environment strongly influences results, sometimes as much as the drug itself. The paper reports on these comparisons, continuing a thirteen-year series of studies with LSD-25 and similar compounds.
LSD (D-lysergic acid diethylamide) was used in the therapy of children, with the authors reporting that it facilitated communication and emotional release in some cases. The text describes the administration of LSD to children with various conditions, suggesting that it could be a useful adjunct to psychotherapy. However, the authors note that the treatment required careful supervision and that results were variable. The paper does not provide quantitative data on outcomes or a controlled comparison.
A simplified method for studying the surfacing reaction of goldfish to hallucinogens uses intracranial injection in fish weighing up to three grams. The drugs d-lysergic acid diethylamide (LSD-25), d-2-acetyl lysergic acid diethylamide (ALD-52), 1-methyl d-lysergic acid butanolamide (UML-491), and 5-methoxy dimethyl tryptamine (5-MEO-DMT) were as pharmacologically active as previously noted in fish and in humans. The relationship of these drugs to their anti-serotonin activity is of particular interest to allergists because the congeners and derivatives of LSD block the action of serotonin on smooth muscle.