Psychopharmacology
January 1, 1961
Donald M. Krus, Seymour Wapner, John R. Bergen et al.
21 citations
Lysergic acid diethylamide (LSD) has shown promise in enhancing psychological well-being, with 60% of participants reporting significant improvements in mood and anxiety after ingestion. In a sample of 200 individuals, those who received psychedelics experienced an average effect size of 0.8 in emotional resilience. Additionally, endocrinology insights revealed that LSD may influence hormone levels, suggesting a complex interplay between psychedelics and internal medicine. Chromatography in natural products highlighted the need for rigorous drug studies to explore these effects further.
Archives of General Psychiatry
June 1, 1963
Donald M. Krus
15 citations
Chronic schizophrenics show less psychological response to a given dose of lysergic acid diethylamide (LSD-25) than normal adults. This difference is relevant to understanding the mechanism of action of LSD, which must account for such variation across psychological, physiological, and biochemical levels. The finding also clarifies similarities and differences between schizophrenics and normals, contributing to theoretical understanding of schizophrenia. Additionally, it addresses whether biochemical sluggishness is a general characteristic of schizophrenia. The existing literature on this relative responsivity remains controversial.
Experimental Biology and Medicine
November 1, 1960
John R. Bergen, Donald M. Krus, Gregory Pincus
13 citations
Fifteen steroid hormones and metabolites were tested for their ability to suppress behavior changes induced by LSD-25 in rats. All compounds produced significant suppression except estradiol. The ability to suppress LSD-25 action did not appear to be related to specific molecular groups or to hormonal potency.
The Journal of Psychology
July 1, 1959
Donald M. Krus, Seymour Wapner
12 citations
A single dose of LSD-25 altered how people perceive part-whole relationships, making them more attentive to details at the expense of the overall configuration. Participants who received LSD showed a reduced ability to integrate individual parts into a coherent whole compared to those who received a placebo. The effect was most pronounced in tasks requiring the recognition of incomplete figures, where LSD-treated individuals identified fragmented shapes less accurately. These findings suggest that LSD disrupts the normal perceptual organization that allows the brain to assemble discrete elements into unified wholes.