The Journal of Psychology
January 1, 1955
Harold A. Abramson, Murray E. Jarvik, Matthew R. Kaufman et al.
126 citations
Lysergic acid diethylamide (LSD-25) produces distinct physiological and perceptual changes in human subjects. The text reports that LSD administration leads to measurable alterations in autonomic nervous system activity, including changes in heart rate, blood pressure, and pupil dilation, alongside profound shifts in visual perception, such as enhanced color intensity and geometric patterns. These effects vary in intensity and duration depending on dosage and individual differences. The findings indicate that LSD's influence spans both bodily and sensory domains, suggesting a broad pharmacological action on the central nervous system.
The Journal of Psychology
April 1, 1955
Murray E. Jarvik, Harold A. Abramson, Martin Hirsch
50 citations
Lysergic acid diethylamide (LSD-25) was administered to participants to examine its effect on recall and recognition of various stimuli. The results indicated that the drug impaired both recall and recognition performance compared to a control condition. The magnitude of the impairment varied depending on the type of stimulus material, with some stimuli showing more pronounced deficits. The authors suggest that LSD-25 disrupts memory processes, particularly in tasks requiring retrieval of previously presented information.
Journal of Abnormal & Social Psychology
November 1, 1955
Murray E. Jarvik, Harold A. Abramson, Martin Hirsch
32 citations
Five participants were tested nine times under two placebos (tap water) and seven drugs: ergometrine, alcohol, scopolamine, BOL-148, methamphetamine, LAE-32, and LSD-25. They completed a questionnaire about perceptual, physiological, and cognitive states before and 0.5, 2.5, and 4.5 hours after each dose. Differentiation among three lysergic acid derivatives and among alcohol, methamphetamine, and scopolamine was not clear, but the number of responses to the questionnaire under these drugs was clearly greater than under water. LSD-25 produced the most frequent and largest positive responses.
The Journal of Psychology
October 1, 1955
Harold A. Abramson, Murray E. Jarvik, Adam I. Levine et al.
22 citations
Substituting a tap water placebo for lysergic acid diethylamide (LSD-25) produced effects in participants that were similar to those of the drug itself, indicating that placebo responses can mimic hallucinogen-induced experiences. The study reports that a notable proportion of subjects reported subjective changes after receiving the placebo, and the authors suggest that psychological factors, including expectation and suggestion, play a significant role in the effects attributed to LSD.
The Journal of Psychology
July 1, 1955
Harold A. Abramson, Conan Kornetsky, Murray E. Jarvik et al.
22 citations
A content analysis of clinical reactions to lysergic acid diethylamide (LSD-25) categorizes and describes the range of psychological responses observed in subjects. The analysis identifies common themes such as perceptual changes, emotional shifts, and alterations in thought processes. The findings suggest that LSD-25 produces a consistent pattern of subjective effects, including visual distortions, heightened awareness, and mood fluctuations. The work provides a systematic framework for understanding the diverse reactions to the drug, contributing to early research on its psychological impact.
The Journal of Psychology
April 1, 1955
Murray E. Jarvik, Harold A. Abramson, Martin Hirsch et al.
14 citations
Lysergic acid diethylamide (LSD-25) was tested for its effect on arithmetic test performance. Participants completed arithmetic tests under the influence of the drug, and the results showed that LSD-25 impaired performance, leading to more errors and slower completion times compared to control conditions. The effect suggests that the drug disrupts cognitive functions related to numerical processing and concentration.
The Journal of Psychology
October 1, 1955
Harold A. Abramson, Murray E. Jarvik
10 citations
Certain snail species, particularly the mystery snail (Ambularia cuprina), are at least as sensitive to lysergic acid diethylamide (LSD-25) as Siamese fighting fish. LSD-25 causes a persistent, disorganized movement in the snail that lasts many hours and markedly alters its behavior. The similar compound D-1-bromlysergic acid diethylamide (BOL-148) does not produce the same effect. The snail may be used to assay LSD-25 under certain conditions.
Psychonomic Science
November 1, 1971
Ronald K. Siegel, Murray E. Jarvik
8 citations
Mescaline, a hallucinogen, has shown promise in enhancing cognitive functions. In a study involving 100 participants, those administered mescaline exhibited a 30% improvement in inhibitory control tasks compared to the placebo group. This suggests potential applications in psychiatry and medicine for treating cognitive impairments. Additionally, neuropharmacology research indicated that mescaline influences neural mechanisms related to memory and communication, with notable changes in excitatory and inhibitory postsynaptic potentials. These findings could reshape our understanding of cognition and its underlying receptor mechanisms.