Concurrent stress modulates the acute and post-acute effects of psilocybin in a sex-dependent manner
Neuropharmacology December 24, 2024 Chloé Galipeau, Zsolt Lenkei, Miguel Farinha‐ferreira et al. 17 citations
Psilocybin increased head-twitch responses in both male and female mice, with a greater effect in females. Stress during the drug's acute effects blocked psilocybin's anxiety-reducing actions in males but only partially in females; no antidepressant-like effects were observed. Both stress and psilocybin independently raised corticosterone levels without additive or interactive effects. The findings highlight how sex and negative experiences during the drug's action influence its acute and post-acute mood effects, underscoring the importance of non-pharmacological factors for therapeutic and recreational use.