Psilocybin rescues sociability deficits in an animal model of autism
bioRxiv (Cold Spring Harbor Laboratory) September 10, 2020 Irene Mollinedo-Gajate, Chenchen Song, Marcos Sintes-Rodriguez et al. 6 citations preprint
In a mouse model of autism spectrum disorder (ASD) created by prenatal exposure to valproic acid, the acute response to the serotonergic psychedelic psilocybin was reduced compared to controls. However, psilocybin treatment reversed the social behavior deficits that are characteristic of the ASD model. These findings suggest that psilocybin may have therapeutic potential for improving social interaction in ASD.