Chemistry and Toxicology of Major Bioactive Substances in Inocybe Mushrooms
International Journal of Molecular Sciences February 23, 2021 Jiří Patočka, Ran Wu, Eugenie Nepovimová et al. 45 citations
Mushroom poisoning remains a global health concern, with numerous annual reports of poisonous mushroom ingestion. This review focuses on the genus Inocybe, which contains toxic substances such as muscarine, psilocybin, psilocin, aeruginascin, lectins, and baeocystin. The article summarizes the chemistry, toxic effects, and mechanisms of these major toxins, particularly muscarine, psilocybin, and psilocin, drawing on previously published toxicity data from different species and administration routes. It also discusses treatment options and potential medical applications of these bioactive compounds, aiming to improve understanding of Inocybe toxicology and support future clinical benefits.