Frontiers in Pharmacology
March 20, 2018
Joaquim Soler, Matilde Elices, Elisabet Domínguez‐clavé et al.
104 citations
A single weekend of four ayahuasca sessions improved the capacity for non-judgmental acceptance as much as an eight-week mindfulness-based stress reduction (MBSR) course, though MBSR produced larger overall gains in mindfulness. Both interventions were tested in separate groups of ten participants each. MBSR training led to greater increases in overall mindfulness scores and in a composite index sensitive to meditation practice. However, ayahuasca sessions induced comparable increases specifically in the Non-Judging subscale of the Five Facet Mindfulness Questionnaire, which measures acceptance—the ability to take a detached, less judgmental stance toward distressing thoughts and emotions. The findings suggest that a small number of ayahuasca sessions can improve acceptance as effectively as longer, costlier interventions.
Mindfulness
February 22, 2016
Marta Alda, Marta Puebla‐guedea, Baltasar Rodero et al.
87 citations
Meditation experts had longer telomeres and fewer short telomeres than matched non-meditators. The psychological factor most strongly linked to telomere maintenance was the absence of experiential avoidance—the tendency to suppress or avoid negative emotions and thoughts—along with a sense of common humanity, as measured by the Self-Compassion Scale. These findings suggest that how meditators relate to their inner experience, rather than meditation itself, may be key to cellular aging.
Mindfulness
March 11, 2018
William van Gordon, Edo Shonin, Thomas J. Dunn et al.
38 citations
Advanced Buddhist meditators can intentionally induce near-death experiences (NDEs) at a planned time, a phenomenon called meditation-induced NDE (MI-NDE). In a study of 12 such meditators, the MI-NDE produced significantly greater increases in NDE profundity, mystical experiences, and non-attachment compared to two other meditation practices. Participants' NDE profundity also increased across a 3-year period. Qualitative analysis revealed that participants were consciously aware of the NDE, retained volitional control over its content and duration, and reported rich non-worldly encounters. The findings corroborate features of regular NDEs and suggest unexplored dimensions, indicating it is feasible and ethical to study real-time neurological activity during NDEs using advanced meditators.
Human Psychopharmacology Clinical and Experimental
May 1, 2026
María Arqueros, J L Fayos Soler, Ausiàs Cebolla et al.
Ego dissolution, a temporary state of reduced self-referential processing and increased unity with the environment, can be modulated by both psychedelics like ayahuasca and contemplative practices like meditation. In a comparison of 37 ayahuasca users and 137 meditators, meditators scored significantly higher on the 'Delusion of Me' index, which measures acceptance, decentering, and non-attachment. While meditation practice showed a significant non-linear association with cumulative practice and higher scores, repeated ayahuasca exposure showed no evidence of a cumulative association with the index in this sample.
April 20, 2026
Jaime Navarrete, Adrián Pérez‐aranda, Daniel Campos et al.
preprint
Spanish versions of three psychological scales—the Quiet Ego Scale (QES), the Nondual Awareness Dimensional Assessment (NADA), and the Ontological Addiction Scale (OAS‑24)—showed good reliability and validity in a sample of 242 Spanish adults. The QES and NADA fit a bifactor structure, while the OAS‑24 fit a one-factor structure. Scores were comparable across genders and meditation experience. Women scored higher on the QES, but no gender differences appeared for the NADA or OAS‑24. Meditators reported higher QES and NADA scores and lower OAS‑24 scores than non-meditators. Low-ego individuals were more likely to meditate and had accumulated more lifetime practice. An optimal threshold of 376 lifetime meditation hours discriminated low- from high-ego profiles.