Posteromedial cortex glutamate and GABA predict intrinsic functional connectivity of the default mode network
NeuroImage September 18, 2012 Dimitrios Kapogiannis, David A. Reiter, Auriel A. Willette et al. 212 citations
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Mark P. Mattson
Johns Hopkins Medicine
2 papers in the library · 379 citations · publishing 2012-2014
Papers
Superior pattern processing is the essence of the evolved human brain
Frontiers in Neuroscience August 22, 2014 Mark P. Mattson 167 citations
The human brain's superior pattern processing (SPP) is the fundamental basis for unique features such as intelligence, language, imagination, invention, and belief in imaginary entities like ghosts and gods. SPP involves the electrochemical, neuronal network-based encoding, integration, and transfer of perceived or mentally-fabricated patterns. During evolution, pattern processing became more sophisticated with expansion of the cerebral cortex, especially the prefrontal cortex and image-processing regions. Patterns are reinforced by emotional experiences, indoctrination, and psychedelic drugs. Impaired SPP is fundamental to cognitive and psychiatric disorders. Understanding SPP mechanisms may enable interventions that reduce irrational decisions and destructive behaviors.