The primary care companion for CNS disorders
January 16, 2024
David F Lo, Hasan Zia, Pranetha Rajkumar et al.
6 citations
A review of 19 studies on psychedelic microdosing found potential benefits for mental health, including improved mood, focus, and daily function, but also reported challenges such as physiologic discomfort and increased anxiety. Some studies observed that positive expectations about microdosing led to positive outcomes. The evidence suggests a positive correlation between microdosing and improved mental well-being, but the causal relationship remains uncertain due to limited controlled studies and small sample sizes. The review calls for further research with double-blind experiments, control groups, and larger, more representative samples.
PCN reports : psychiatry and clinical neurosciences
September 1, 2024
Jaylyn Thompson, David F Lo, Alexis Foschini et al.
1 citation
A review of eight randomized controlled trials examined whether ketamine given during or after cesarean section can reduce postpartum depression. Some trials found that women who received ketamine had lower scores on the Edinburgh Postpartum Depression Scale shortly after delivery—for example, one trial reported a significantly lower score on day 4—while two other trials found no significant difference at 3 days postpartum. The review suggests that ketamine may help prevent or lessen postpartum depression symptoms after cesarean section, but more research is needed to clarify the relationship between dosage and effect.
Research Posters
May 2, 2024
David F Lo, Hasan Zia, Adarsh Thakur et al.
1 citation
A systematic review of 16 articles examined the effects of psychedelic microdosing on mental health. Microdosing with LSD and psilocybin, and less commonly mescaline, DMT, and amphetamines, is used by roughly 5.5 million individuals in the U.S. to treat mental health issues. The studies indicated lower levels of anxiety, depression, and stress among those who microdose, but drawbacks such as difficulty sleeping and headaches were reported. The review notes that studies with larger sample sizes and double-blind designs are needed for a greater understanding of this treatment modality.