THE DISTRIBUTION AND METABOLISM OF LYSERGIC ACID DIETHYLAMIDE
Annals of the New York Academy of Sciences March 1, 1957 Julius Axelrod, Roscoe O. Brady, B. Witkop et al. 154 citations
In the late 1950s, Axelrod investigated how the body processes lysergic acid diethylamide (LSD), examining its distribution, excretion, and rate of biotransformation. He detailed the subcellular processes involved in transforming LSD, determined the order of drug concentrations in various tissues, and found that the body almost completely metabolizes the drug. Additionally, he discovered considerable differences between animal species in the rate of LSD biotransformation.