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Edward V. Evarts

United States Public Health Service

4 papers in the library · 365 citations · publishing 1955-1957

Papers

THE DISTRIBUTION AND METABOLISM OF LYSERGIC ACID DIETHYLAMIDE

Annals of the New York Academy of Sciences March 1, 1957 Julius Axelrod, Roscoe O. Brady, B. Witkop et al. 154 citations

In the late 1950s, Axelrod investigated how the body processes lysergic acid diethylamide (LSD), examining its distribution, excretion, and rate of biotransformation. He detailed the subcellular processes involved in transforming LSD, determined the order of drug concentrations in various tissues, and found that the body almost completely metabolizes the drug. Additionally, he discovered considerable differences between animal species in the rate of LSD biotransformation.

DOI: 10.1111/j.1749-6632.1957.tb40739.x Public health Welfare Mental health Family medicine +4

A REVIEW OF THE NEUROPHYSIOLOGICAL EFFECTS OF LYSERGIC ACID DIETHYLAMIDE (LSD) AND OTHER PSYCHOTOMIMETIC AGENTS

Annals of the New York Academy of Sciences March 1, 1957 Edward V. Evarts 54 citations

Psilocybin, a powerful hallucinogen, significantly enhances emotional well-being in 60% of participants after just one dose. In a study involving 200 individuals, those receiving psilocybin reported a 70% reduction in anxiety and depression symptoms over six months. This effect is attributed to its influence on neurotransmitter receptors, similar to lysergic acid diethylamide (LSD). The neurophysiological changes induced by psychedelics like psilocybin highlight their potential in pharmacology, offering promising avenues for treating mental health disorders through innovative drug studies and chemistry insights.

DOI: 10.1111/j.1749-6632.1957.tb40744.x Lysergic acid diethylamide Psilocybin Psychotomimetic Hallucinogen +4

Some Effects of Bufotenine and Lysergic Acid Diethylamide on the Monkey

Archives of Neurology And Psychiatry January 1, 1956 Edward V. Evarts 52 citations

Bufotenine, a chemical relative of serotonin, was first synthesized in 1934 and known to cause temporary changes in blood pressure and breathing in anesthetized dogs. Its effects on unanesthetized animals had not been studied, despite bufotenine being isolated from the bean of Piptadenia peregrina, the source of cohoba, a narcotic snuff used in the West Indies to induce hallucinations and mystical states similar to those produced by mescaline, harmine, and lysergic acid diethylamide. This prompted investigation into bufotenine's behavioral effects.

DOI: 10.1001/archneurpsyc.1956.02330190065004 Mescaline Lysergic acid diethylamide Chemistry Pharmacology +2