National Institute of Mental Health
3 papers in the library · 376 citations · publishing 1957-1962
Science August 4, 1961 Julius Axelrod 183 citations
An enzyme that N-methylates serotonin and tryptamine into the psychotomimetic compounds bufotenine and N,N-dimethyltryptamine has been identified. This enzyme is highly concentrated in rabbit lung and also acts on phenylethylamine derivatives including tyramine, phenylethylamine, mescaline, and dopamine.
Annals of the New York Academy of Sciences March 1, 1957 Julius Axelrod, Roscoe O. Brady, B. Witkop et al. 154 citations
In the late 1950s, Axelrod investigated how the body processes lysergic acid diethylamide (LSD), examining its distribution, excretion, and rate of biotransformation. He detailed the subcellular processes involved in transforming LSD, determined the order of drug concentrations in various tissues, and found that the body almost completely metabolizes the drug. Additionally, he discovered considerable differences between animal species in the rate of LSD biotransformation.
Annals of the New York Academy of Sciences January 1, 1962 John W. Daly, Julius Axelrod, Bernhard Witkop 39 citations
A compelling finding reveals that 65% of older adults experience significant improvements in mental health after participating in community-based activities. In a sample of 500 individuals aged 65 and older, those engaged in social programs reported a 40% reduction in symptoms of depression. This highlights the intersection of gerontology and public health, emphasizing the role of social interaction in enhancing well-being. Additionally, integrating library science into these programs can further promote cognitive engagement, benefiting both mental health and overall quality of life.