Additional file 2 of An open-label pilot study of psilocybin-assisted therapy for binge eating disorder
Figshare January 1, 2026 Jesse Dallery, Jennifer L. Miller, Jeff Boissoneault et al.
No Summary
Jennifer L. Miller
University of Florida
3 papers in the library · publishing 2026
Papers
Additional file 1 of An open-label pilot study of psilocybin-assisted therapy for binge eating disorder
Figshare January 1, 2026 Jesse Dallery, Jennifer L. Miller, Jeff Boissoneault et al.
No Summary
An open-label pilot study of psilocybin-assisted therapy for binge eating disorder
Figshare January 1, 2026 Jesse Dallery, Jennifer L. Miller, Jeff Boissoneault et al.
A single 25 mg dose of psilocybin, combined with Acceptance and Commitment Therapy, was tested in five adults with binge-eating disorder. The treatment was well tolerated with no serious adverse events. All participants reported reduced binge eating frequency that lasted through 14 weeks. Improvements also occurred in depression, anxiety, and psychological inflexibility. Three participants lost weight and reduced waist circumference. Brain scans showed increased activity in regions linked to cognitive control and self-awareness when viewing processed versus unprocessed food cues. Because the study was small and open-label, causality cannot be determined, but the results support larger controlled trials.