Elisa Roda

Laboratory of Clinical & Experimental Toxicology, Pavia Poison Centre, National Toxicology Information Centre, Toxicology Unit, Istituti Clinici Scientifici Maugeri, IRCCS, Pavia, Italy.

3 papers in the library · 8 citations · publishing 2024-2026

Papers

Pharmaco-toxicological effects of the novel tryptamine hallucinogen 5-MeO-MiPT on motor, sensorimotor, physiological, and cardiorespiratory parameters in mice-from a human poisoning case to the preclinical evidence.

Psychopharmacology March 1, 2024 Marta Bassi, Sabrine Bilel, Micaela Tirri et al. 7 citations

5-MeO-MiPT, a new psychedelic tryptamine first identified in Italy in 2014, dose-dependently inhibits sensorimotor responses and prepulse inhibition in male CD-1 mice, and at high doses (30 mg/kg) impairs stimulated motor activity and causes cardiorespiratory changes. In silico ADMET predictions indicate its toxicokinetic profile resembles those of 5-MeO-DIPT and DMT, with a cytochrome-related risk. Correspondence between effects in mice and symptoms from a human intoxication case suggests consumption can impair activity performance and pose health risks, but the authors argue the compound should not be excluded from psychiatric therapy research.

DOI: 10.1007/s00213-024-06526-8 Full text 5-MEO-Mipt Admet prediction Behaviour Cardiorespiratory changes +11

Repeated administration of the synthetic cannabinoid AKB48 induces serotonergic neuroadaptation in male and female mice: behavioural and immunohistochemical evidence.

Neuropharmacology February 1, 2026 Giorgia Corli, Fabrizio De Luca, Sabrine Bilel et al. 1 citation

Repeated exposure to the synthetic cannabinoid AKB48 worsens the visual sensorimotor, sensory gating, and motor reactivity response to the hallucinogens 2C-I and 25I-NBOMe in mice. This effect is more prolonged in males than in females. The underlying mechanism involves neuroplastic changes in the cerebellum and cortex, specifically at serotonin 2A receptors and the serotonin transporter. These changes occur more markedly and rapidly in female mice. The findings highlight a significant interaction between synthetic cannabinoids and psychedelic drugs, which may be relevant to long-term effects and psychiatric consequences of their consumption.

DOI: 10.1016/j.neuropharm.2025.110758 Full text 25i-nbome pubchem cid 2c-i pubchem cid 5-ht2a receptors Akb48 pubchem cid +5

3-CMC: Acute Effects in Male and Female Mice, Human Intoxication Case Series (Italy, 2014–2025), and Prediction of ADMET Properties

International Journal of Molecular Sciences November 29, 2025 M. Bassi, Elisa Roda, Giorgia Corli et al.

3-chloromethcathinone (3-CMC), a synthetic cathinone involved in many poisonings, causes locomotor stimulation, rapid breathing, hypothermia, and sensorimotor alterations in mice, with prepulse inhibition changes only at high doses and minor sex differences. All 15 human intoxications in Italy from 2014 to 2025 were non-fatal, involving male patients with psychomotor agitation, psychosis, aggressiveness, CNS depression, cardiac arrhythmias, chest pain, and tachypnea. Predicted metabolic reactions include N-dealkylation, N-hydroxylation, and phenyl hydroxylation, and all compounds show potential for drug-drug interactions and cardiotoxicity.

DOI: 10.3390/ijms262311600 Cardiotoxicity Prepulse inhibition Psychomotor learning Acute toxicity +5