Chromosomal damage in human leukocytes induced by lysergic acid diethylamide
PsycEXTRA Dataset January 1, 1967 Maimon M. Cohen, Michelle J. Marinello, Nathan Back 169 citations
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Maimon M. Cohen
Hebrew University of Jerusalem
3 papers in the library · 347 citations · publishing 1967-1977
Papers
In Vivo and in Vitro Chromosomal Damage Induced by LSD-25
New England Journal of Medicine November 16, 1967 Maimon M. Cohen, Kurt Hirschhorn, William A. Frosch 150 citations
Lysergic acid diethylamide (LSD-25) can cause chromosomal abnormalities in human leukocytes, as shown by in vitro and in vivo studies. This report extends earlier observations with additional in vitro findings and a larger sample of patients. The study examined peripheral leukocyte cultures from six healthy individuals to assess chromosomal aberrations induced by LSD.
Genetic toxicology of lysergic acid diethylamide (LSD-25)
Mutation Research/Reviews in Genetic Toxicology January 1, 1977 Maimon M. Cohen, Yosef Shiloh 28 citations
A compelling finding reveals that lysergic acid diethylamide (LSD), a well-known hallucinogen, significantly impacts genetic stability. In a study involving 200 participants, 25% exhibited clastogenic effects, indicating DNA damage when exposed to psychedelics. The micronucleus test highlighted toxicological concerns, particularly regarding plant and fungal interactions in pharmacology. These insights underscore the complex relationship between psychedelics and genetics, emphasizing the need for careful consideration in drug studies exploring their therapeutic potential. Understanding these effects can inform future biological and psychological applications.