LSD in Mice: Abnormalities in Meiotic Chromosomes
Science June 14, 1968 Niels E. Skakkebæk, J. Philip, Ole J. Rafaelsen 62 citations
In mice injected with high doses of LSD-25, meiotic chromosomes showed several breaks, gaps, and unidentifiable fragments that were largely absent in control animals. Secondary constrictions were also more numerous in the treated mice. These findings suggest that high doses of LSD-25 can cause chromosomal abnormalities during meiosis, with possible implications for genetic integrity.