Drug Testing and Analysis
May 13, 2019
Simon D. Brandt, Pierce V. Kavanagh, Folker Westphal et al.
72 citations
1-Butanoyl-LSD (1B-LSD), a new analog of lysergic acid diethylamide (LSD), was fully characterized using multiple analytical techniques including NMR, mass spectrometry, and infrared spectroscopy, allowing clear differentiation from a similar compound, 1P-ETH-LAD. In behavioral tests with C57BL/6J mice, 1B-LSD produced a dose-dependent increase in head-twitch response, a marker of serotonergic hallucinogen activity, though with only about 14% of LSD's potency (ED50 = 976.7 nmol/kg vs. 132.8 nmol/kg for LSD). This suggests 1B-LSD has LSD-like behavioral effects and may act as a pro-drug for LSD, but further research is needed to confirm psychoactive effects in humans.
Drug Testing and Analysis
March 16, 2020
Simon D. Brandt, Pierce V. Kavanagh, Folker Westphal et al.
38 citations
1-Cylopropanoyl-LSD (1CP-LSD), a new lysergamide-based designer drug, was analyzed using multiple chemical and spectroscopic methods. Incubation with human serum converted 1CP-LSD into LSD, suggesting it may act as a prodrug for LSD in the body. In mice, 1CP-LSD induced a head-twitch response (HTR) with an ED50 of 430.0 nmol/kg, comparable to 1P-LSD (ED50 = 349.6 nmol/kg), indicating an LSD-like behavioral profile. The study includes analysis of blotters and pellets, and detected artificially induced degradation products during GC-MS analysis. Clinical studies are needed to determine its potency and effects in humans.
Talanta
February 1, 2013
Alain Gaujac, Nicola M. Dempster, Sandro Navickiene et al.
29 citations
A method using solid-phase microextraction (SPME) combined with gas chromatography ion trap mass spectrometry (GC-IT-MS) reliably detects and measures N,N-dimethyltryptamine (DMT) in ayahuasca and vinho da jurema, plant-based beverages used in South American religious ceremonies. The technique, optimized with a PDMS/DVB fiber at 60°C for 70 minutes, achieves good precision (relative standard deviation below 8.6%), accuracy (71–109%), and a detection limit of 0.78 mg/L. Analysis of twelve real samples from Brazilian religious groups found DMT concentrations ranging from 0.10 to 1.81 g/L. The method minimizes sample handling and is robust for quantifying DMT in these increasingly globally available beverages.