Complex discriminative stimulus properties of (+)lysergic acid diethylamide (LSD) in C57Bl/6J mice
Psychopharmacology January 11, 2005 Michael A. Benneyworth, Randy L. Smith, Robert J. Barrett et al. 38 citations
The drug discrimination procedure, a common method for studying hallucinogens, was extended to mice. Mice required a nearly five-fold higher dose of LSD than rats to learn the discrimination. The LSD stimulus effects were dose-dependent and short-lived. A 5-HT(2A/2C) receptor agonist fully substituted for LSD, while a 5-HT(1A) agonist partially substituted. Antagonists selective for 5-HT(2A) or 5-HT(1A) receptors each only partially blocked LSD discrimination, indicating that both receptor types contribute to LSD's effects in mice.