Methylenedioxymethamphetamine (MDMA) in Psychiatry
Journal of Clinical Psychopharmacology October 10, 2018 Susan Schenk, David Newcombe 53 citations
MDMA (ecstasy) shows some promise as an aid to psychotherapy for posttraumatic stress disorder (PTSD) by increasing prosocial feelings, possibly through oxytocin release and reduced fear conditioning. However, MDMA also carries risks of neurotoxicity and potential for misuse. The article weighs the pros and cons of using MDMA for PTSD, noting that while some evidence suggests it can help patients address underlying trauma, its significant adverse effects raise concerns. Alternative treatments based on MDMA's pharmacology but with fewer side effects are proposed. Further research into the mechanisms behind MDMA's beneficial effects may lead to safer treatment options.