In male mice from seven genetically diverse laboratory strains, mescaline (35 mg/kg) inhibited emotional defecation and stimulated open field activity in five strains (A2G, C3H/He, C57BR/cd, CBA/Cam, F/St) but not in two others (ICFW, Schneider). The degree of emotional defecation under saline control correlated positively with mescaline's inhibitory effect. Pre-treatment with tranylcypromine did not alter emotional defecation or mescaline's inhibition of it.
Male mice from seven inbred strains (A2G, C57BR, C3H, F/st, CBA, ICFW, and Schneider) were tested for hexobarbitone sleeping time. The same strains had previously been tested for the inhibitory effect of mescaline on emotional defecation. A strong correlation between the two measures across strains was found, which was unexpected theoretically and may have important implications for pharmacogenetics.