Effects of Hallucinogenic and Tranquilizing Drugs on Serotonin Evoked Uterine Contractions.
Experimental Biology and Medicine January 1, 1956 E. Costa 64 citations
The tranquilizing drugs Frenquel, chlorpromazine, and reserpine block serotonin-induced contractions in the uterus of spayed rats, without affecting responses to acetylcholine or oxytocin. Reserpine's blocking effect lasts longer than chlorpromazine's, and Frenquel's is shortest. Mescaline enhances serotonin's effects and, at high doses, directly contracts the uterus, an action not blocked by atropine. High concentrations of LSD (1 γ/L) antagonize both serotonin- and mescaline-induced uterine activity, whereas low concentrations (0.05 to 0.2 γ/L) facilitate these effects.