Microchemical Journal
February 28, 2023
María Mata-Pesquera, David Fabregat‐safont, Cristina Gil et al.
10 citations
A recently detected synthetic cathinone, N-cyclohexyl butylone, was characterized using gas chromatography–mass spectrometry, liquid chromatography–high-resolution mass spectrometry, nuclear magnetic resonance, and Fourier-transform infrared spectroscopy. The compound's elemental composition and molecular structure were determined from accurate-mass ions and two-dimensional NMR experiments. In silico predictions suggest that N-cyclohexyl butylone likely produces stimulant effects similar to MDMA. This work provides a complete analytical profile for a new psychoactive substance that has appeared in European drug markets.
Drugs Education Prevention and Policy
October 30, 2023
Henry Harder, Fabian P. Steinmetz, Maja Kohek
3 citations
As many jurisdictions decriminalize plant- and fungus-based psychedelics like psilocybin-containing mushrooms, Oregon has become the first U.S. state to legalize and regulate their cultivation, supply, and use in designated service centers. A non-profit legal framework for production, supply, and non-medical use may be more advantageous than a for-profit one, especially for a naturally occurring mushroom that is not frequently used. People who use drugs can demonstrate agency in self-supply and in adopting responsible use and harm reduction practices. Community or peer-based structures may offer a viable approach to ensuring controlled supply and a safe environment for non-medical use.
Molecular Informatics
January 17, 2019
James W. Firman, Samuel J. Belfield, George Chen et al.
A growing number of novel psychoactive substances (NPS) are entering circulation, yet their pharmacological profiles and risks are often unknown. To aid prediction of properties for uncharacterized analogues, a chemical inventory of 690 distinct NPS with defined structures was compiled from governmental and analytical reports, supplemented by 155 established psychoactive drugs of abuse (EPDA). Classification by molecular features, subjective effects, and pharmacological mechanisms identified over forty chemical groupings, seven effect categories, and six mechanisms. Co-occurrence of NPS and EPDA within classes was common, highlighting potential for chemical read-across and derivation of structural alerts.