Synthesis and Action on the Central Nervous System of Mescaline Analogues Containing Piperazine or Homopiperazine Rings
Journal of Pharmaceutical Sciences March 1, 1983 Michal W. Majchrzak, A Kotełko, Roman Guryn et al. 5 citations
A series of mescaline analogues were synthesized by attaching a piperazine or homopiperazine ring to the 3,4,5-trimethoxyphenyl group. Pharmacological tests of central nervous system action showed that replacing the amino group in mescaline with these heterocycles significantly alters biological activity. Both the piperazine and homopiperazine derivatives displayed sedative activity to about the same extent. The study compared six-membered piperazine and seven-membered homopiperazine rings to determine whether the larger ring conferred special properties.