Zenodo (CERN European Organization for Nuclear Research)
November 25, 2025
Swygert, John
A new quantitative model proposes that the body's own DMT, acting through sigma-1 receptors, can increase coherence between neural activity and an underlying substrate. The model integrates neuropharmacology and quantum biology to explain how sigma-1 receptor chaperone activity stabilizes microtubule coherence and improves phase alignment between brain oscillations and substrate eigenmodes. The paper provides a kinetic derivation, an experimental protocol, and five falsifiable predictions, all compatible with established biophysics. It suggests DMT is a biologically regulated modulator of neural-substrate phase coupling, offering a unified mechanism for altered-state phenomena.
Zenodo (CERN European Organization for Nuclear Research)
November 23, 2025
Swygert, John
A new biological classification for DMT is proposed: crisis-linked endogenous consciousness modulators (cECMs). DMT uniquely satisfies six falsifiable criteria: endogenous neural biosynthesis, deep evolutionary conservation, ultra-rapid pharmacokinetics, multi-receptor promiscuity, crisis-linked release, and induction of information-rich structured internal states. 5-MeO-DMT meets five criteria and is designated borderline; classic psychedelics (psilocin, LSD, mescaline) and conventional neuromodulators fail most criteria. Published evidence of mammalian brain biosynthesis, sigma-1 receptor regulation, TAAR signaling, and ischemia-linked surges supports the framework. Four concrete, testable predictions are presented. The cECM model offers a precise, predictive alternative to the current "classic psychedelic" taxonomy.
Zenodo (CERN European Organization for Nuclear Research)
November 23, 2025
Swygert, John
A standardized, open-source scientific protocol enables rigorous investigation of structured visual patterns reported by people under the influence of DMT when viewing diffused coherent red laser light. The protocol specifies safety, legal, optical, camera, dosing, physiological monitoring, blinding, and phenomenology requirements. It mandates sober negative controls, lens inspection, continuous multi-camera recording, and a standardized data format for academic review. The protocol aims to allow researchers, including skeptics, to generate reproducible, falsifiable evidence about the interaction between psychedelics, coherent light interference, visual neuroscience, and altered sensory gating.
Zenodo (CERN European Organization for Nuclear Research)
November 23, 2025
Swygert, John
A standardized, open-source scientific protocol has been developed for investigating reports of structured visual patterns seen within diffused red laser light under the influence of DMT. The protocol specifies safety, legal, optical, dosing, monitoring, blinding, and documentation requirements to ensure reproducibility and falsifiability. It mandates sober negative controls, lens inspection, continuous multi-camera recording, and a standardized data format for academic review. The protocol aims to generate confirming or falsifying evidence about the DMT–laser visual phenomenon and serves as a foundation for a global dataset on psychedelics, coherent light interference, visual neuroscience, and altered sensory gating.
Zenodo (CERN European Organization for Nuclear Research)
November 22, 2025
Swygert, John
A new hypothesis proposes that the brain's own DMT acts as a piezoelectric molecular antenna, coupling living systems to a non-local field that generates the sense of self. Drawing on biochemistry, clinical lobotomy data, and cross-species comparisons, the paper argues DMT-linked circuits enable self-modeling; severing them, as in lobotomy, collapses inner experience despite preserved behavior. The model yields testable predictions about self-awareness, DMT synthesis, and crystalline structure disruption, offering a falsifiable framework for consciousness research.
Zenodo (CERN European Organization for Nuclear Research)
November 20, 2025
Swygert, John
This paper completes Federico Faggin's architecture of consciousness by identifying two missing components: a biological receiver (the DMT antenna network) and an interaction law (encoded equilibrium, expressed as V = E × Y). The DMT antenna hypothesis proposes that endogenous DMT synthesis in biological systems creates crystalline and piezoelectric microstructures capable of transducing non-local information. The encoded equilibrium equation defines how biological systems extract information from a consciousness field, governing coherence, self-modeling, and the emergence of subjective experience. The work synthesizes quantum information theory, neurochemistry, plant electrophysiology, clinical lobotomy data, and near-death experience phenomenology, offering falsifiable predictions.