Neural correlates of consciousness: progress and problems
Nature reviews. Neuroscience April 20, 2016 Christof Koch, Marcello Massimini, Mélanie Boly et al. 1,654 citations
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Mélanie Boly
University of Wisconsin–Madison
4 papers in the library · 2,177 citations · publishing 2008-2022
Papers
The spectral exponent of the resting EEG indexes the presence of consciousness during unresponsiveness induced by propofol, xenon, and ketamine
NeuroImage January 11, 2019 Michele Colombo, Martino Napolitani, Mélanie Boly et al. 359 citations
During anesthesia, people may still be conscious even though they do not respond. A marker of consciousness based on the decay rate of the power spectral density (PSD) of resting EEG—measured by the spectral exponent β—was tested in healthy participants under xenon, propofol, or ketamine anesthesia (n=5 per group). Delayed reports indicated whether consciousness was present or absent. Xenon and propofol, which abolish consciousness, caused a steeper PSD decay (more negative β) compared to wakefulness. Ketamine, which preserves consciousness, showed a PSD decay similar to wakefulness overall but a flattening in high frequencies (20–40 Hz). The spectral exponent correlated strongly with the Perturbational Complexity Index (PCI), supporting its use as a marker of consciousness.
Quantifying arousal and awareness in altered states of consciousness using interpretable deep learning
Nature Communications February 25, 2022 Minji Lee, Leandro Sanz, Alice Barra et al. 120 citations
A deep-learning-based explainable consciousness indicator (ECI) uses EEG responses to transcranial magnetic stimulation and resting-state EEG to separately quantify arousal and awareness. Tested during sleep (n=6), general anesthesia (n=16), and severe brain injury (n=34), ECI distinguishes states such as ketamine-induced anesthesia and rapid eye movement sleep, which combine low arousal with high awareness. Parietal brain regions are most relevant for these measurements. The indicator offers a way to disentangle the two components of consciousness across physiological, pharmacological, and pathological conditions.
Brain Function in Physiologically, Pharmacologically, and Pathologically Altered States of Consciousness
International Anesthesiology Clinics January 1, 2008 Pierre Boveroux, Vincent Bonhomme, Mélanie Boly et al. 44 citations
A peer-reviewed article examines the intersection of medicine, consciousness, and brain function, focusing on altered states such as those arising from cardiovascular syncope, autonomic disorders, hallucinations in medical conditions, and traumatic brain injury with neurovascular disturbances. The work discusses how these conditions affect cognitive science, psychology, and legal implications, without presenting a single empirical finding or specific numerical data. The argument integrates neuroscience and philately as a metaphor for collecting insights, suggesting that altered states of consciousness can inform understanding of brain function and autonomic regulation.