The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network: Evidence from a partial correlation network analysis
NeuroImage June 13, 2008 Peter Fransson, Guillaume Marrelec 1,236 citations
Functional connectivity within the default mode network was assessed during rest and a continuous working memory task using partial correlation analysis. The precuneus/posterior cingulate region showed strong interactions with the rest of the network, while the left and right medial temporal lobes interacted strongly with each other but weakly with other regions. Strong interactions were also found between the precuneus/posterior cingulate cortex and the left inferior parietal lobe, and between dorsal and ventral sections of the medial prefrontal cortex. These findings support a pivotal role for the precuneus/posterior cingulate cortex in the default mode network.