Functional connectivity within the default mode network was assessed during rest and a continuous working memory task using partial correlation analysis. The precuneus/posterior cingulate region showed strong interactions with the rest of the network, while the left and right medial temporal lobes interacted strongly with each other but weakly with other regions. Strong interactions were also found between the precuneus/posterior cingulate cortex and the left inferior parietal lobe, and between dorsal and ventral sections of the medial prefrontal cortex. These findings support a pivotal role for the precuneus/posterior cingulate cortex in the default mode network.
Experienced meditators with over 1000 hours of training show weaker functional connectivity between default mode network (DMN) regions involved in self-referential processing and emotional appraisal compared to beginners with no prior experience. They also show increased connectivity between certain DMN regions, such as the dorso-medial prefrontal cortex and right inferior parietal lobule. These resting-state functional connectivity changes suggest that extensive meditation training may strengthen present-moment awareness by altering how core DMN regions communicate, even when not actively meditating.