Psilocybin as a Tool in the Management of Palliative Care: An Historical, Pharmacological and Clinical Approach
Medical & Clinical Case Reports Journal May 19, 2025 Andrés David Turizo Smith, Natalia Jaramillo, Diana Milena Berrío Cuartas
Psilocybin, a psychedelic compound found in certain mushrooms, has a long history of use in spiritual ceremonies and neuropsychiatric therapy. After being classified as a Schedule I substance in 1970, research into its therapeutic potential has revived since the early 2000s, especially in psychiatry and palliative care. This review examines psilocybin's potential to improve quality of life for palliative care patients by reducing psychological distress and enhancing emotional well-being. The discussion covers its historical context, pharmacokinetics, pharmacodynamics, legal status, and future perspectives in palliative care.