Sex differences in the acute effects of oral THC: a randomized, placebo-controlled, crossover human laboratory study.
Psychopharmacology October 1, 2024 Ardavan Mohammad Aghaei, Lia Urban Spillane, Brian Pittman et al. 9 citations
After a single 10 mg oral dose of THC, women reported a heightened subjective feeling of being 'high' compared to men, while psychotomimetic and physiological effects were similar across sexes. No sex differences appeared in verbal learning and memory. The findings suggest that women may experience a more pronounced subjective psychoactive response to THC, pointing to individual vulnerabilities that could inform tailored interventions for cannabis use disorder.