Influence of Carrier Oil, Sex, and Age on Pharmacokinetic and Acute Behavioral Effects of Vaporized Cannabis Extract in Mice.
Cannabis and cannabinoid research December 1, 2025 Sara R Westbrook, Allison L Jensen, Vanessa Copeland-Solorzano et al. 2 citations
Vaporized cannabis e-liquid produces stronger effects and higher blood THC levels when mixed with polyethylene glycol 400 (PEG) rather than propylene glycol/vegetable glycerin (PG/VG). In mice, the highest dose tested caused body temperature drops, pain relief, and reduced movement. Adolescents were less sensitive than adults to the movement-suppressing effects, possibly due to lower circulating THC. No sex differences appeared in behavioral responses, but female mice showed slower THC metabolism than males, suggesting sex differences in how cannabis is broken down.