Journal of Psychoactive Drugs
January 29, 2025
Carrie Cuttler, Amanda Stueber, Jonathan Simone et al.
3 citations
An online survey of 1,486 U.S. adults (average age 29.58, 67.1% male) examined patterns of psychedelic use. Respondents most often used MDMA, LSD, DMT, and psilocybin, primarily by oral administration and for recreational purposes. The most common acute effects were hallucinations, increased heart rate, positive mood, and visual tracers; residual effects included headaches, dry mouth, nausea, hallucinations, and anxiety. Distress about negative mood, vomiting, and nausea during acute effects was low on average. These findings can inform clinical trials and policy as psychedelic legality and accessibility evolve.
Cannabis and cannabinoid research
December 1, 2025
Sara R Westbrook, Allison L Jensen, Vanessa Copeland-Solorzano et al.
2 citations
Vaporized cannabis e-liquid produces stronger effects and higher blood THC levels when mixed with polyethylene glycol 400 (PEG) rather than propylene glycol/vegetable glycerin (PG/VG). In mice, the highest dose tested caused body temperature drops, pain relief, and reduced movement. Adolescents were less sensitive than adults to the movement-suppressing effects, possibly due to lower circulating THC. No sex differences appeared in behavioral responses, but female mice showed slower THC metabolism than males, suggesting sex differences in how cannabis is broken down.
Proceedings of the National Academy of Sciences of the United States of America
December 30, 2025
Catherine Hume, Carrie Cuttler, Samantha L Baglot et al.
Cannabis vapor inhalation acutely increases food intake in both humans and rats, an effect driven by central cannabinoid 1 receptors. In humans, energy intake rose within the first 30 minutes of snack access, regardless of dose or gender, without altering the proportion of macronutrients consumed. In rats, cannabis vapor reduced the time to start eating and increased the number of feeding bouts, overriding homeostatic appetite regulation by boosting motivation to eat and reducing food reward devaluation. These feeding effects were not accompanied by changes in circulating appetite-associated hormones, and they depended on central, not peripheral, CB1 receptors.