Menstrual Changes and Reversal of Amenorrhea Induced by Classic Psychedelics: A Case Series
Journal of Psychoactive Drugs January 22, 2023 Natalie Gukasyan, Sasha K. Narayan 9 citations
Three women aged 27 to 34 reported distinct changes in menstrual function after using classic psychedelics: resumption of menses after amenorrhea, early onset of menses when psychedelics were used in the mid to late luteal phase, and improved menstrual regularity in a woman with irregular cycles later diagnosed with polycystic ovarian syndrome. The mechanisms remain unclear but may involve 5-HT2A receptor effects on the hypothalamic-pituitary-gonadal axis. These effects, largely overlooked in psychedelic research, may have therapeutic potential and need further investigation.