Journal of affective disorders
July 15, 2025
Hongjuan Wang, Hui Wang, Jojo Yan Yan Kwok et al.
5 citations
Mindfulness-based interventions (MBIs) improve several health outcomes for women going through menopause, including reducing menopausal symptoms, anxiety, depressive symptoms, stress, and sleep problems, while enhancing quality of life and mindfulness levels. These findings come from a meta-analysis of 18 randomized controlled trials involving 1,670 participants. The interventions showed good acceptability, with a low dropout rate (6%) and high adherence (79%). However, the overall quality of evidence was rated low to moderate due to methodological limitations and small sample sizes, so more rigorous research with longer follow-up is needed to confirm these benefits and understand how MBIs work.
Advanced Science
September 25, 2025
Ye Wang, Lei Liu, Jinghao Wang et al.
2 citations
Early administration of S-Ketamine (on day 1) after trauma significantly improves PTSD symptoms in rodent models, particularly impaired fear extinction, while late administration (day 7) does not. The firing and burst rates of dopamine neurons in the ventral tegmental area (VTA) decrease after PTSD modeling and are restored only by early S-Ketamine. These VTA dopamine neurons respond to conditioned stimuli and help replace aversive memory encoding during fear extinction. Inhibiting the VTA-to-orbitofrontal cortex (OFC) pathway blocks S-Ketamine's therapeutic effect. A non-invasive brain stimulation targeting the OFC sensitizes cortical dopaminergic transmission and extends the effective time window of S-Ketamine for anti-PTSD treatment.
Journal of visualized experiments : JoVE
January 9, 2026
Tingjun Zhang, Shujuan Yan, Hui Wang et al.
In elderly patients undergoing laparoscopic prostate cancer surgery, adding intravenous esketamine to conventional anesthesia was associated with reduced need for other anesthetics (remifentanil, propofol, and muscle relaxants), better hemodynamic stability (higher heart rate and blood pressure just after intubation, lower values one hour into surgery), slightly longer awakening time but less agitation and severe coughing, shorter postanesthesia care unit stays, lower pain scores immediately and at 6 and 24 hours after surgery, higher scores on a mental status exam at 1 and 7 days postoperatively, and a lower incidence of postoperative cognitive dysfunction. The only adverse event that differed was more mild drowsiness in the esketamine group. The findings suggest esketamine may benefit recovery and cognitive outcomes in this population.