Journal of analytical toxicology
May 20, 2022
Hannes M Schwelm, Nicole Zimmermann, Tobias Scholl et al.
13 citations
The poison of the Colorado River toad (Incilius alvarius) contains a variety of psychoactive tryptamines, with 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) as the main component at an average concentration of 410,000 μg per gram of poison. Using multiple analytical methods, researchers identified nine tryptamine compounds, including 5-MeO-tryptamine and two positional isomers of hydroxylated MeO-DMT detected for the first time in this species. Concentrations of other tryptamines such as bufotenin (2,800 μg/g), 5-MeO-tryptamine (490 μg/g), 5-HO-N-methyltryptamine (270 μg/g), and DMT (250 μg/g) varied considerably between individual toad samples. These comprehensive reference data may assist forensic chemists in analyzing toad venom samples.
Drug testing and analysis
March 1, 2023
Pierce V Kavanagh, Folker Westphal, Benedikt Pulver et al.
7 citations
A new lysergamide, 1cP-AL-LAD, was analyzed using chromatographic, mass spectrometric, and spectroscopic methods. A powdered sample from an online vendor contained 17 impurities, including AL-LAD and 1P-AL-LAD (confirmed by reference standards) and tentatively identified compounds such as 1-acetyl-AL-LAD and oxidation products of the N6-allyl group and ergoline ring. The substance was also found in blotter paper samples sold online for recreational use. These findings provide analytical data for researchers interested in lysergamide chemistry.
Drug testing and analysis
February 1, 2024
Simon D Brandt, Pierce V Kavanagh, Folker Westphal et al.
5 citations
N-ethyl-N-isopropyllysergamide (EIPLA), an isomer of the psychedelic lysergamide ETH-LAD, shows LSD-like properties in preclinical tests. Mass spectrometry, chromatography, and NMR spectroscopy distinguished EIPLA from ETH-LAD by their structural features. Blotter extracts contained 96.9 ± 0.5 μg and 85.8 ± 2.8 μg of EIPLA base. In mice, EIPLA induced head-twitch responses (ED50 = 234.6 nmol/kg), about half the potency of LSD (ED50 = 132.8 nmol/kg), consistent with serotonergic psychedelic effects. Analytical data are provided to aid forensic and clinical identification.