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James C. Callaway

1 paper in the library · 134 citations · publishing 1998

Papers

Ayahuasca Preparations and Serotonin Reuptake Inhibitors: A Potential Combination for Severe Adverse Interactions

Journal of Psychoactive Drugs December 1, 1998 James C. Callaway, Charles S. Grob 134 citations

The Amazonian psychoactive beverage ayahuasca may dangerously interact with SSRI antidepressants. Its harmala alkaloids inhibit monoamine oxidase, and combining them with selective serotonin reuptake inhibitors can trigger serotonin syndrome, a potentially life-threatening condition. Caution is advised when using ayahuasca alongside certain pharmaceutical drugs.