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C. Van Peteghem

2 papers in the library · 14 citations · publishing 1980-1982

Papers

GLC-mass Spectral Determination of Mescaline in Plasma of Rabbits after Intravenous Injection

Journal of Pharmaceutical Sciences January 1, 1980 C. Van Peteghem, A. Heyndrickx, W. Van Zele 11 citations

A gas-liquid chromatography–mass spectrometry method using a deuterated internal standard accurately measures mescaline concentrations in rabbit plasma. After intravenous administration, mescaline and the internal standard are extracted with benzene, derivatized with trifluoroacetic acid anhydride, and separated on a 2.5% QF-1 column with mass fragmentographic detection. The detection limit is 5 ng/ml of plasma, and the relative standard deviation is about 5%. The method's main advantage is combining the specificity of gas-liquid chromatography retention time and mass spectral fragmentation with the sensitivity of mass fragmentographic detection.

DOI: 10.1002/jps.2600690139 Trifluoroacetic anhydride Chemistry Chromatography Detection limit +4

Pharmacokinetic parameters of mescaline in rabbits

European Journal of Drug Metabolism and Pharmacokinetics January 1, 1982 C. Van Peteghem, A. Heyndrickx, W. Van Zele 3 citations

Mescaline in rabbit plasma follows a two-compartment open model after intravenous injection. Half-life times for the alpha and beta phases, velocity constants, and steady-state distribution volumes are reported for four subjects, measured using a highly specific and sensitive mass fragmentographic method.

DOI: 10.1007/bf03189535 Mescaline Pharmacokinetics Steady state chemistry Distribution mathematics +8