Synergism of Amines and Antagonism of Reserpine to Morphine Analgesia
Experimental Biology and Medicine January 1, 1958 E. B. Sigg, G. Caprio, J. A. Schneider 78 citations
Reserpine blocks the pain-relieving effects of morphine, meperidine, and codeine in mice. In contrast, several amines including 5-hydroxytryptophane, 5-hydroxytryptamine, tryptamine, amphetamine, mescaline, and epinephrine lengthen and strengthen morphine's analgesic effect, while iproniazid and choline-p-tolyl-ether do not. The authors discuss possible mechanisms for these interactions, focusing on how amines enhance and reserpine opposes morphine analgesia.