Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
October 1, 2023
Tim Hirschfeld, Johanna Prugger, Tomislav Majić et al.
24 citations
LSD produces a sigmoid-like increase in altered states of consciousness that plateaus around 100 micrograms, with the strongest effects on perception and illusory imagination, followed by positive ego-dissolution. Anxiety and dread of ego dissolution show only small effects. Considerable variability in most measures indicates that non-pharmacological factors also shape subjective experiences. These dose-response relationships can serve as general references for future research to compare observed with expected effects and to explore phenomenological differences between psychedelics.
bioRxiv (Cold Spring Harbor Laboratory)
November 7, 2022
Tim Hirschfeld, Johanna Prugger, Tomislav Majić et al.
4 citations
preprint
Lysergic acid diethylamide (LSD) produces a sigmoid-like increase in altered states of consciousness, with effects plateauing around 100 micrograms. The strongest changes involve perception and illusory imagination, followed by positively experienced ego-dissolution, while anxiety and dread of ego dissolution show only small effects. Considerable variability in responses highlights the importance of non-pharmacological factors. These dose-response relationships can serve as references for future research on LSD.
February 22, 2023
Madlen Peters, Johanna Prugger, Petar Radoev Dimkov et al.
3 citations
preprint
The Altered States Database (ASDB) is an open science project that compiles psychometric questionnaire data on altered states of consciousness experiences induced by various methods. This update reports a systematic literature review following PRISMA guidelines, where 431 items were screened and data from 23 eligible journal articles were extracted, covering literature up to December 31, 2022. The complete dataset is publicly available on the Open Science Framework.
May 3, 2024
Kasey Devitt, Johanna Prugger, Tim Hirschfeld et al.
preprint
The Altered States Database (ASDB) is an open data initiative that collects psychometric questionnaire data on subjective experiences from pharmacologically and non-pharmacologically induced altered states of consciousness. The current update adds data published in 2023, identified through a systematic literature review following PRISMA guidelines. Of 454 items screened, 13 journal articles were included: ten report on the 11-ASC, eight on the 5D-ASC, six on the MEQ-30, and one on the PCI. The ASDB now contains data on 22 substances and 13 techniques, from 198 journal articles and 847 datasets, accessible online.