A psychedelic drug, psilocybin, and a comparison drug, methylphenidate, produce distinct acute and persistent changes in brain networks measurable with precision functional mapping, a technique that improves signal detection by repeatedly scanning individuals. Seven healthy adults underwent extensive baseline brain imaging, imaging shortly after drug intake, and follow-up scans for up to two weeks. Four participants repeated the psilocybin protocol months later. The dataset includes resting-state and task-based functional MRI, structural scans, and subjective experience reports. The authors release this resource to help researchers study how psilocybin and methylphenidate alter brain network organization over time.
The Altered States Database (ASDB) is an open-science project that provides psychometric questionnaire data on subjective experiences of altered states of consciousness (ASC) induced by pharmacological and non-pharmacological methods. Developed through a systematic literature review following PRISMA guidelines, the database includes data from 165 journal articles identified via PubMed and Web of Science. It contains responses from validated questionnaires such as the APZ, 5D-ASC, 11-ASC, PCI, HRS, and MEQ30. The data is freely available on the Open Science Framework and the ASDB website, enabling calculation of comparable psychometric values and dose-response relationships for substances that induce ASC.