Science
June 9, 1972
J.m. Neal, Patricia Sato, William N. Howald et al.
16 citations
Alkaloid extracts from the Mexican peyote cactus Pelecyphora aselliformis Ehrenberg contain hordenine, anhalidine, pellotine, 3-demethyltrichocereine, mescaline, 3,4-dimethoxy-β-phenethylamine, and the N-monomethyl derivatives of mescaline and 3,4-dimethoxy-β-phenethylamine. This is the first report of mescaline and several other alkaloids occurring in a North American cactus outside the genus Lophophora.
Science
March 15, 1968
Philip H. Abelson
15 citations
No Summary
Science
June 1, 1962
D. W. Woolley, N.k. Campbell
13 citations
Certain compounds that mimic psychosis, which are structurally similar to serotonin, sometimes produce effects like the hormone and sometimes oppose it, depending on the test used.
Science
January 13, 1967
L. P. Gilmour, R. D. O’brien
7 citations
Psilocybin, a hallucinogenic compound, produced a blue color when mixed with a specific subfraction of rat-brain mitochondria that likely contains nerve-ending particles. The color formation intensified with higher pH, did not need oxygen, and involved an insoluble component. Chemically related neuroactive substances like bufotenine and serotonin did not cause this effect, and only tyramine or ethylenediaminetetraacetic acid blocked the reaction.
Science
September 19, 2024
Stacey B. Armstrong, Alan K. Davis
6 citations
Psychedelic-assisted therapy (PAT) combines hallucinogenic drugs like psilocybin and MDMA with psychotherapy, showing potential for treating mental health conditions that affect one in eight people worldwide. Clinical trials in the US and Europe suggest PAT may offer shorter treatment times and stronger effects than existing therapies. However, the field faces significant controversy due to unanswered questions about safety and effectiveness, highlighted by the FDA's recent decision against approving MDMA therapy for PTSD and the retraction of several MDMA trial papers due to unethical therapist conduct and data integrity issues. The research community must address these obstacles to transition from exploratory trials to established, evidence-based treatments.
Science
September 22, 1967
Thomas N. Chase, George R. Breese, Irwin J. Kopin
1 citation
Slices of rat brain that had taken up radioactive serotonin, either in a living animal or in a laboratory dish, were washed and then electrically stimulated. This caused a substantial release of the added serotonin, and to a smaller degree its breakdown products. The amount released depended on which brain region was tested, and the release was blocked by lysergic acid diethylamide (LSD).
Science
May 7, 2026
A small study focusing on Black and low-income participants produced results described as remarkable.