Psychiatry Research Case Reports
July 15, 2022
Mika Turkia
14 citations
A teenager with early complex trauma from chronic domestic violence developed auditory hallucinations after using cannabis and was diagnosed with an acute schizophrenia-like psychotic disorder. Antipsychotic medication did not fully resolve symptoms. The teenager then self-medicated with LSD, carrying out six unsupervised sessions, followed by almost daily use of inhaled low-dose DMT. Psychotic symptoms mostly resolved after about one year, though subsequent cannabis use caused a transient relapse. LSD and DMT did not promote psychotic symptoms and resolved the suicidal condition in one session. High-dose LSD and low-dose DMT sessions appeared to resolve symptoms related to early complex trauma, possibly by providing access to traumatic memories. Information came from medical record excerpts, a semi-structured retrospective video interview, and follow-up interviews a year later.
Psychiatry Research Case Reports
April 26, 2023
Eric N. Kramer, Kalyn Reddy, Bryan Shapiro
7 citations
A 30-year-old man with no psychiatric history attempted suicide by stabbing himself in the neck after ingesting psilocybin. Although most existing evidence suggests psilocybin use lowers suicidality risk, this case indicates that serious adverse events such as suicide attempts may occur. Further research is needed to determine whether psilocybin can increase suicidality risk, and if that risk depends on dose or the user's mindset and environment.
Psychiatry Research Case Reports
December 7, 2024
4 citations
Three cases from a dual diagnosis inpatient psychiatry unit in 2023 illustrate distinct adverse effects of psilocybin use. Intermittent use led to prolonged psychosis requiring higher and longer neuroleptic treatment; frequent short-term use culminated in paranoia and a serious suicide attempt treated with neuroleptics; long-term microdosing preceded mania-like symptoms—grandiosity, irritability, physical aggression—that resolved after stopping psilocybin. As psilocybin becomes more accepted and prevalent, clinicians lack guidelines for managing its complications. This case series describes varied presentations, management strategies, and treatment responses to provide insight into this unknown territory.
Psychiatry Research Case Reports
July 26, 2023
Gregory W. Kirschen, Mary E. Shorey, Joan C. Han et al.
A woman with a history of childhood sexual abuse and a past suicide attempt developed a dissociative identity episode upon emerging from anesthesia. The episode lasted 90 minutes and resolved on its own; she was discharged safely two days later. This case suggests that anesthesia can be a trigger for dissociative identity disorder (DID) in vulnerable individuals, adding to known psychosocial precipitants. The authors propose a mechanism involving anesthesia's effects on functional brain connectivity as a unifying hypothesis.