The psychedelic renaissance: psilocybin, a breakthrough for treatment resistant depression?
Exploration of neuroscience August 7, 2025 Trevor R. Norman 2 citations
A single dose of psilocybin, given alongside intensive psychotherapy, produces a rapid and clinically significant decline in depressive symptoms in people with treatment resistant depression, with benefits mostly retained at 12 weeks or longer. Psilocybin was well tolerated; side effects were mostly mild to moderate and transient, including elevated blood pressure, fatigue, headache, nausea, and vertigo. Hallucinogen persisting perception disorder was occasionally reported, and there were few reports of suicidal ideation and behavior. Further controlled evaluations are necessary before routine use.