LSD-25 and JB 318, a newer psychotomimetic drug with atropine-like effects, were compared in the same population using identical measurement techniques. The LSD-induced psychosis serves as a standard reference for psychotomimetic agents, and direct comparison clarifies similarities and differences between the two drugs' effects on mood, thought, perception, and behavior. Administering both agents to the same subjects helps infer which aspects of the drug-induced state are shared or distinct.
The behavioral effects of LSD-25 have been studied using organismic and developmental theory. This paper focuses on the apparent horizon—the point in space perceived to be at eye level—as a measure of spatial organization. This dimension has been examined under conditions of success and failure, with energizing and tranquilizing drugs, and in depressed and elated manic-depressive groups, as well as in children aged 6 to 20 years. The present work extends this line of research by testing implications of the theoretical framework in a situation involving the apparent horizon.