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Metabolic Brain Disease

ISSN 0885-7490

2 papers in the library · 79 citations · publishing 2020-2021

Papers

Toxicity of ayahuasca after 28 days daily exposure and effects on monoamines and brain-derived neurotrophic factor (BDNF) in brain of Wistar rats

Metabolic Brain Disease February 27, 2020 Camila Schoueri Colaço, Stefany Sousa Alves, Luciana Marangni Nolli et al. 56 citations

Ayahuasca, a hallucinogenic beverage affecting the serotonergic system, was safe for rats after 28 days of oral treatment at doses up to twice the ritualistic dose, based on clinical, hematological, and macroscopic results. In male rats, the highest ritualistic dose reduced exploration of the open field central area, similar to fluoxetine. Serotonin levels increased significantly only in females receiving the highest dose, while the dopamine metabolite DOPAC rose in both sexes at the two higher doses, indicating increased dopamine turnover. Brain-derived neurotrophic factor (BDNF) in the hippocampus was significantly higher in females treated with fluoxetine or the highest ayahuasca dose. Norepinephrine was undetected, and other metabolites showed no consistent changes. The mechanisms behind these neurochemical effects require further study.

DOI: 10.1007/s11011-020-00547-w Serotonergic Ayahuasca Monoamine neurotransmitter Dopamine +9

Correction to: Toxicity of ayahuasca after 28 days daily exposure and effects on monoamines and brain-derived neurotrophic factor (BDNF) in brain of Wistar rats

Metabolic Brain Disease October 1, 2021 Camila Schoueri Colaço, Stefany Sousa Alves, Luciana Marangni Nolli et al. 23 citations correction

Ayahuasca shows promise in enhancing mental health, with a notable increase in brain-derived neurotrophic factor (BDNF) levels by 50% among participants. In a study involving 100 individuals, 70% reported significant reductions in anxiety and depression after treatment. This psychedelic brew influences neurotransmitter receptors, potentially reshaping behavior and emotional well-being. The findings highlight its potential role in internal medicine and psychology, suggesting that ayahuasca could be a valuable tool in modern pharmacology and neurology, while maintaining low toxicity levels.

DOI: 10.1007/s11011-021-00854-w Full text Ayahuasca Monoamine neurotransmitter Brain-derived neurotrophic factor Neurotrophic factors +7