Journal of the Brazilian Chemical Society
January 1, 2017
André D. Cavalcante, Gabriele A. Cardoso, Fernando de Oliveira et al.
11 citations
N,N-dimethyltryptamine (DMT) content in Psychotria viridis, a key ingredient in ayahuasca, varies with environmental and cultivation factors. Leaf samples from 25 locations across 14 Brazilian states and the Federal District were collected over four seasons. DMT levels were measured by gas chromatography-mass spectrometry and correlated with environmental parameters, plant nutrients, and farming methods. Seasonality, altitude, latitude, and biome type had the strongest effects on DMT content. A positive correlation between nitrogen and magnesium levels and DMT concentration was found. Regression analysis identified foliar nutrient levels that would yield DMT concentrations in cultivated plants similar to those of Amazonian specimens.
Journal of the Brazilian Chemical Society
January 1, 2015
Diego A. Sánchez Robayo, William F. Garzón Mendez, Gonzalo Taborda Ocampo et al.
9 citations
Blotter paper samples seized in Bogotá were analyzed using gas chromatography–mass spectrometry, revealing phenethylamine derivatives from the 2,5-dimethoxy-N-(2-methoxybenzyl) series. The prevalent compounds were 2-(4-chloro-2,5-dimethoxy-N-(2-methoxybenzyl)) phenethylamine, 2-(4-bromo-2,5-dimethoxy-N-(2-methoxybenzyl)) phenethylamine, and 2-(4-iodo-2,5-dimethoxy-N-(2-methoxybenzyl)) phenethylamine. These derivatives are known powerful hallucinogens not yet under international control.
Journal of the Brazilian Chemical Society
January 1, 2018
Sandro Navickiene, Luı́s M. N. B. F. Santos, Mônica C. Santos et al.
2 citations
A solid-phase extraction method using ultra-performance liquid chromatography-tandem mass spectrometry was developed to quantify five major alkaloids—N,N-dimethyltryptamine, harmine, harmaline, harmalol, and tetrahydroharmine—in ayahuasca. Two new adsorbent materials, coconut charcoal and menthone-thiosemicarbazone polymer, were tested. Recoveries ranged from 40.6% to 116.2%, with detection limits between 0.003 and 0.016 μg mL⁻¹ and quantification limits between 0.009 and 0.043 μg mL⁻¹. The method was linear over 0.05–1.0 μg mL⁻¹ (correlation coefficients 0.9969–0.9998). Applied to an ayahuasca sample from a religious group in Fortaleza, Brazil, alkaloid concentrations ranged from 0.3 to 19.3 mg mL⁻¹.
Journal of the Brazilian Chemical Society
January 1, 2026
Mateus Araújo Da Luz, Taynah Pereira Galdino, Lucas Matheus da S. Oliveira et al.
Optimizing the extraction of psilocybin from Psilocybe cubensis mushrooms using an acidified ethanol solvent at pH 2 and 25 °C, without added water, yields up to 50.03 mg of psilocybin per gram of extract (about 1% psilocybin). This exceeds yields reported in similar studies. Analysis by liquid chromatography-mass spectrometry identified six compounds: the known indole alkaloids psilocybin and psilocin, plus four compounds not previously reported in the Psilocybe genus—sn-glycero-3-phosphocholine, norvaline, tetronomycin, and N-(tetradecanoyl)-sphinganine.