Quantification of LSD and N-demethyl-LSD in urine by gas chromatography/resonance electron capture ionization mass spectrometry
Hyun Kyoon Lim, David M. Andrenyak, Paula Francom, Rodger L. Foltz, Reese T. Jones
Analytical Chemistry July 15, 1988 DOI: 10.1021/ac00165a015 via OpenAlex
Summary
AI-generated from the abstractA gas chromatography/resonance electron capture ionization mass spectrometry method was developed to quantify LSD and its metabolite N-demethyl-LSD in urine. The method achieved detection limits of 0.1 ng/mL for LSD and 0.2 ng/mL for N-demethyl-LSD, with linear calibration curves over a range of 0.5 to 20 ng/mL. The technique was applied to urine samples from human subjects administered known doses of LSD, demonstrating reliable identification and measurement of both compounds. The approach offers improved sensitivity and specificity for forensic and clinical detection of LSD use.
Study at a glance
| Characteristics | Method development and validation Peer reviewed |
|---|---|
| Keywords | Icon Citation Altmetrics Social media Mass spectrometry |
| Citations | 68 |
| Key finding | The GC/MS method can detect LSD and N-demethyl-LSD in urine at sub-nanogram per milliliter concentrations with high specificity. |
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantification of LSD and N-demethyl-LSD in urine by gas chromatography/resonance electron capture ionization mass spectrometryHeng Keang. Lim, David. Andrenyak, Paula. Francom, Rodger L. Foltz, and Reese T. JonesCite this: Anal. Chem. 1988, 60, 14, 1420–1425Publication Date (Print):July 15, 1988Publication History Published online1 May 2002Published inissue 15 July 1988https://pubs.acs.org/doi/10.1021/ac00165a015https://doi.org/10.1021/ac00165a015research-articleACS PublicationsRequest reuse permissionsArticle Views263Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts